Sterile Liquid and Solid Production
Facilities
PHARMASEUTICAL PRODUCTION WITH STATE OF ART TECHNOLOGY

With departments of sterile liquid and solid  production Onko has 2 production facilities with state of art technology and equipments. Onko is the only one pharmaceutical company that uses isolator technology in Turkey. Purpose of this technology is to avoid environmental contamination and also to protect the employees.

LOCAL ONCOLOGY INVESTMENT AWARD

Onko has a capability to produce capsule and tablet forms with granulation, tablet and capsule filling lines. The facility also holds an award for local investment in the field of oncology.

The Facilities Holds
EU GMP Certificates.
According to EU GMP Guideline Onko has a A, B, C, D cleanroom design for specific process steps.

Facility A

Onko vial filling line capability for filling is between 2 ml – 250 ml and also we have a filling capability between 0,2 ml – 5 ml for  prefilled syringe (PFS). This two filling lines are dedicated for only aseptic filling. In addition to this information; if necessary, Onko can perform terminal sterilization for filled products.

After filling process optic inspection, labeling, blistering and boxing operations performed in Onko packing area.

Onko produce non-high potent products in this facility. Facility infrastructure consists of generally European brand machinery.

Facility B

Sterile Liquid Production Department

Onko vial filling line capability for filling is between 6 ml – 100 ml and also we have a filling capability between 0,2 ml – 1 ml for  prefilled syringe (PFS). In addition to this information; Onko has a capability to perform lyophlization process for vial products. This two lines are dedicated for only aseptic filling. If necessary, Onko can perform terminal sterilization for filled products as well.

After filling process optic inspection, labeling, blistering and boxing operations performed in Onko packing area.

Aseptic production is done via isolator technology which is the last trend in the world. Regarding to EU GMP Guideline, inside of the isolator must be A grade and outside of the machine must be at least D grade zone. Onko provides this specific cleanroom design for isolator technology. Also Onko uses isolator technology for weighing and solution preparation processes.

Onko is the only one pharmaceutical company that uses isolator technology in Turkey. Purpose of this technology is to avoid environmental contamination and also to protect the employees.

 Onko produce high potent products in this facility. Facility infrastructure consist of generally European brand machinery. Single use hoses, connections, filters and bags has been designed for the isolator technology.

Facility B

Solid Production Department

Onko has a capability to produce each size capsule and tablet forms with granulation, tablet and capsule filling lines. In addition to that if necessary Onko able to tablet coating with coating equipment.

After tablet pressing, blistering and boxing is performed. Solid production is done with containment systems & isolator technology which is the last trend in the world. Solid production area is class 100.000. Onko uses isolator technology for weighing processes.

Onko is the only one pharmaceutical company that uses this technology in Turkey. Purpose of this technology is to avoid environmental contamination and also to protect the employees.

Onko produce high potent solid products in this facility. Facility infrastructure consist of generally USA and European brand machinery. The equipments that Onko uses for high potent product is designed for to protect OEL 4/5 which is the highest level for exposure level.


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SINIF ALAN

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